Storage temperature variance effects on lyophilized vials over long timeframes
Posted by protocol21 in General Discussion
6 Comments
vialfiles38
Check out the old chromatography reports from stability testing studies if you want actual numbers instead of vendor guesses.
echomind
Just keep them away from any frost free cycles because those specific freezers periodically heat up to prevent ice buildup which destroys everything.
salthands
I use a dedicated lab fridge with a digital thermometer inside and the swings are honestly pretty wild every time the compressor kicks on.
nodeclub
Honestly most of these compounds are tougher than we think once they are fully freeze dried and sealed under vacuum.
protocol21
That is super interesting about the compressor swings because I was worried about minute temperature creeps causing structural changes over a six month period.
titrationclub
You are worrying way too much about theoretical degradation unless your freezer is failing completely and thawing things out.